e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Use of the hydantoin isostere to produce inhibitors showing selectivity toward the vesicular glutamate transporter versus the obligate exchange transporter system
SK Ahmed, JLG Etoga, SA Patel, RJ Bridges…
Index: Ahmed, S. Kaleem; Etoga, Jean-Louis G.; Patel, Sarjubhai A.; Bridges, Richard J.; Thompson, Charles M. Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 14 p. 4358 - 4362
Abstract Evidence was acquired prior to suggest that the vesicular glutamate transporter (VGLUT) but not other glutamate transporters were inhibited by structures containing a weakly basic α-amino group. To test this hypothesis, a series of analogs using a hydantoin (pK a∼ 9.1) isostere were synthesized and analyzed as inhibitors of VGLUT and the obligate cystine–glutamate transporter (system View the MathML source
