e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Heavy-atom kinetic isotope effects in the acid-catalyzed rearrangement of N-2-naphthyl-N'-phenylhydrazine. Rearrangement is shown to be a concerted process
HJ Shine, L Kupczyk-Subotkowska…
Index: Shine, Henry J.; Kupczyk-Subotkowska, Lidia; Subotkowski, Witold Journal of the American Chemical Society, 1985 , vol. 107, # 23 p. 6674 - 6678
Abstract: Heavy-atom kinetic isotope effects (KIE) have been measured in the acid-catalyzed rearrangement of N-2-naphthyl-”-phenylhydrazine (1) into l-(o-aminophenyl)-2- naphthylamine (2). A combination of whole-molecule-ion and isotope ratio mass spectrometry and scintillation counting has given KIE for I5N,” C, and I4C. Use of [15N,” N'] 1 and whole-molecule-ion mass spectrometry gave a KIE of 1.0434 (for two I5N atoms). Use ...