Antifungal Agents. 10. New Derivatives of 1-[(Aryl)[4-aryl-1 H-pyrrol-3-yl] methyl]-1 H-imidazole, Synthesis, Anti-Candida Activity, and Quantitative Structure-Analysis …

…, M Botta, R Di Santo, F Corelli, S Massa…

Index: Di Santo, Roberto; Costi, Roberta; Artico, Marino; Massa, Silvio; Musiu, Chiara; Milia, Carlo; Putzolu, Monica; La Colla, Paolo Medicinal Chemistry Research, 1997 , vol. 7, # 2 p. 98 - 108

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Citation Number: 73

Abstract

The synthesis, anti-Candida activity, and quantitative structure-activity relationship (QSAR) studies of a series of 2, 4-dichlorobenzylimidazole derivatives having a phenylpyrrole moiety (related to the antibiotic pyrrolnitrin) in the α-position are reported. A number of substituents on the phenyl ring, ranging from hydrophobic (tert-butyl, phenyl, or 1-pyrrolyl moiety) to basic (NH2), polar (CF3, CN, SCH3, NO2), or hydrogen bond donors and acceptor (OH) groups, ...