The Journal of Organic Chemistry

(2S, 3S, 4R)-4-Amino-3-hydroxy-2-methylvalerate. Synthesis of an amino acid constituent of bleomycin from L-rhamnose

T Ohgi, SM Hecht

Index: Ohgi, Tadaaki; Hecht, Sidney M. Journal of Organic Chemistry, 1981 , vol. 46, # 6 p. 1232 - 1234

Full Text: HTML

Citation Number: 31

Abstract

(12) Wong, M.; Thomas, J. K.; Nowak, T. J. Am. Chem. SOC. 1977,99, 4730. (13) According to Albery: y is a function of the curvature in the (In k"/ko) vs. n plots. If the observed isotope effect is due to protons with the same 4 value (eF, the protons in flight of TS 2 designated A) y will be given by y Y AA /a, where a is the number of the protons involved, and AA is given by A* = (a In +A)/ln (k'/ko). Using @A = 0.67 and In (k'/ko) = -1.231, we obtamed y = 0.32. (14) On the ...