Synthesis, crystal structure and anti-inflammatory properties of curcumin analogues

…, H Zhou, L Shao, K Huang, J Xiao, Z Huang…

Index: Liang, Guang; Yang, Shulin; Zhou, Huiping; Shao, Lili; Huang, Kexin; Xiao, Jian; Huang, Zhifeng; Li, Xiaokun European Journal of Medicinal Chemistry, 2009 , vol. 44, # 2 p. 915 - 919

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Citation Number: 75

Abstract

Curcuminoids have been reported to possess multifunctional bioactivities, especially the ability to inhibit proinflammatory induction. Since it has been suggested that the seven- carbon β-diketone linker in curcumin is responsible for its instability, nine mono-carbonyl five- carbon linker containing analogues were designed and synthesized. Their bioactivity against lipopolysaccharide-induced TNF-α amd IL-6 secretion was evaluated by using ...