Synthesis of 2-Bromomethyl-3-Hydroxy-2-Hydroxymethyl-Propyl Pyrimidine and Theophylline Nucleosides Under Microwave Irradiation. Evaluation of Their Activity …

…, A Abdel-Rahman, LF Awad, HA Rasheed

Index: Ashry; Rashed; Abdel-Rahman; Awad; Rasheed Nucleosides, Nucleotides and Nucleic Acids, 2006 , vol. 25, # 8 p. 925 - 939

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Citation Number: 7

Abstract

Alkylation of 2-methylthiopyrimidin-4 (1H)-one (1a) and its 5 (6)-alkyl derivatives 1b–d as well as theophylline (7) with 2, 2-bis (bromomethyl)-1, 3-diacetoxypropane (2) under microwave irradia-tion gave the corresponding acyclonucleosides 1-[(3-acetoxy-2- acetoxymethyl-2-bromomethyl) prop-1-yl]-2-methyl-thio pyrmidin-4 (1 H)-ones 3a–d and 7- [(3-acetoxy-2-acetoxymethyl-2-bromomethyl) prop-1-yl] theophylline (8), which upon ...