Synthesis, in vitro anti-inflammatory and cytotoxic evaluation, and mechanism of action studies of 1-benzoyl-β-carboline and 1-benzoyl-3-carboxy-β-carboline …

ML Yang, PC Kuo, TL Hwang, WF Chiou, K Qian…

Index: Yang, Mei-Lin; Kuo, Ping-Chung; Hwang, Tsong-Long; Chiou, Wen-Fei; Qian, Keduo; Lai, Chin-Yu; Lee, Kuo-Hsiung; Wu, Tian-Shung Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 5 p. 1674 - 1682

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Citation Number: 37

Abstract

In the present study, various 1-substituted and 1, 3-disubstituted β-carboline derivatives were synthesized by a modified single-step Pictet–Spengler reaction. The compounds were examined for cytotoxicity and anti-inflammatory activity, as measured by the inhibition of prostaglandin E2 (PGE2) production and nitric oxide (NO) production. While only two compounds (28 and 31) showed marginal cytotoxicity against four human cancer cell lines ...