On the synthesis of pyridinylthiobarbituric acids

LW Deady, D Ganame, NH Quazi, SD Zanatta

Index: Deady, Leslie W.; Ganame, Daniel; Hughes, Andrew B.; Quazi, Nurul H.; Zanatta, Shannon D. Australian Journal of Chemistry, 2002 , vol. 55, # 4 p. 287 - 289

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Citation Number: 7

Abstract

Abstract The reaction of N-(pyridin-3-yl) and-4-yl thiourea derivatives with malonyl dichloride in trifluoroacetic acid is shown to be an efficient synthesis of the corresponding thiobarbituric acids. The pyridin-2-yl analogue cleaved and produced, instead, 2-hydroxy-4H-pyrido [1, 2a] pyrimidin-4-one.