. ALPHA.-Glucosidase Inhibitors with a 4, 5, 6, 7-Tetrachlorophthalimide Skeleton Pendanted with a Cycloalkyl or Dicarba-closo-dodecaborane Group.

…, H Takahashi, R Yamasaki, H Kagechika…

Index: Sou, Sonei; Takahashi, Hiroyasu; Yamasaki, Ryu; Kagechika, Hiroyuki; Endo, Yasuyuki; Hashimoto, Yuichi Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 6 p. 791 - 793

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Citation Number: 48

Abstract

Previous studies of α-glucosidase inhibitors derived from thalidomide revealed that 4, 5, 6, 7- tetrachloro-N-alkylphthalimide derivatives are superior lead compounds. Structure-activity relationship studies indicated that a hydrophobic group at the N (2) position is mandatory for potent activity. Accordingly, we have designed and synthesized some 4, 5, 6, 7-tetrachloro-N- cycloalkylphthalimide and 4, 5, 6, 7-tetrachloro-N-dicarba-closo-dodecaborane ...