Azines and azoles: CXXII. New regioselective synthesis of 1-substituted 6-alkyluracils

VN Yuskovets, AV Moskvin, LE Mikhailov…

Index: Yuskovets; Moskvin; Mikhailov; Ivin Russian Journal of General Chemistry, 2005 , vol. 75, # 1 p. 134 - 146

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Citation Number: 3

Abstract

Abstract Readily available 5-acyl-4-hydroxy-3, 6-dihydro-2 H-1, 3-thiazine-2, 6-diones with primary alkyl-and arylamines in mild conditions (boiling in propan-2-ol) to give Schiff bases. In more rigid conditions (boiling in DMF), the reaction is accompanied by COS liberation and provides 1-substituted 6-alkyluracils. This previously unknown reaction possesses a considerable synthetic potential and can be considered as a new, general, and ...