Synthesis and structure–activity relationship of 2-thiopyrimidine-4-one analogs as antimicrobial and anticancer agents

S Prachayasittikul, A Worachartcheewan…

Index: Prachayasittikul, Supaluk; Worachartcheewan, Apilak; Nantasenamat, Chanin; Chinworrungsee, Maneekarn; Sornsongkhram, Nirun; Ruchirawat, Somsak; Prachayasittikul, Virapong European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 738 - 742

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Citation Number: 40

Abstract

Considering that some thiopyrimidines were previously reported as potential therapeutics, the present study achieved novel analogs of bioactive 2-substituted thiopyrimidines-4-(3H)- ones via base catalyzed alkylation reaction of 2-thiouracil using alkyl and aralkyl bromides. The title compounds were 2-(1-butylthio) pyrimidine-4 (3H)-one (5a), 2-(2-butylthio) pyrimidine-4 (3H)-one (5b), 2-(cyclohexylmethylthio) pyrimidine-4 (3H)-one (5c), 2-( ...