Journal of medicinal chemistry

Irreversible enzyme inhibitors. CLV. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 1-[4-. omega.-aminoalkoxy)-3-chlorophenyl]-4, 6- …

BR Baker, EE Janson

Index: Journal of medicinal chemistry, , vol. 12, # 4 p. 672 - 676

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Citation Number: 1

Abstract

... Chemistry.-The irreversible inhibitors in Table I, except for 4, can be generalized by structures 34-36 ... (12) E. E. Janson, MS Thesis, University of California at Santa Barbara, (13) E. J. Modest. J . Ow. Chem., 91, 1 (1956). (14) (a) E. Katchalski and D. Ben-Ishai, ibid.. ...