H I11 pyridoxine was therefore undertaken. The 5-hydroxythiazoles were virtually an unknown class of compounds when this work was started, and it therefore seemed of chemical, as well as of antimalarial, interest to investigate the preparation of 2-methyl-4- hydroxymethyl-5-hydroxythia-zole ILb One approach to the 5-hydroxythiazole structure would be the treatment of a-amino esters with dithioformic acid6 followed by cyclization of ...
