Synthesis, cytotoxic evaluation, and molecular docking study of 4, 5-diaryl-thiazole-2-thione analogs of combretastatin A-4 as microtubule-binding agents

…, A Assadieskandar, T Cheraghi-Shavi…

Index: Salehi, Marjan; Ostad, Seyed Nasser; Riazi, Gholam Hossein; Assadieskandar, Amir; Cheraghi-Shavi, Tayebeh; Shafiee, Abbas; Amini, Mohsen Medicinal Chemistry Research, 2014 , vol. 23, # 3 p. 1465 - 1473

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Citation Number: 6

Abstract

Abstract A series of combretastatin A-4 analogs in which cis-olefinic bond replaced by thiazole ring were prepared by reaction of α-bromo-1, 2-(p-substituted) diaryl-1-ethanones and dithiocarbamate derivatives. The cytotoxicity of these compounds was determined against three cancer cell lines (HT-29),(MCF-7),(AGS) as well as fibroblastic cell line (NIH- 3T3) using MTT assay. Inhibition of tubulin polymerization for some potent compounds ...