Synthesis and anticonvulsant activity of N-Benzylpyrrolo [2, 3-d]-,-pyrazolo [3, 4-d]-, and-triazolo [4, 5-d] pyrimidines: imidazole ring-modified analogs of 9-(2- …

JL Kelley, RG Davis, EW McLean…

Index: Kelley; Davis; McLean; Glen; Soroko; Cooper Journal of Medicinal Chemistry, 1995 , vol. 38, # 19 p. 3884 - 3888

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Citation Number: 34

Abstract

18: R= NH,, Xi F yields. The reaction was best run with pure, distilled benzylhydrazine because in situ generation of 11 from the hydrochloride salt gave 13 contaminated with the 2- isomer. Assignment of the structure of 13 as the 1-isomer was established via a NOE experiment. Irradiation of the methylene gave NOE's of 7% and 2% for the aryl and NH2 protons. When the aminopyrazoles 13 and 14 were refluxed with formamide or N- ...