The decomposition of N-hydroxyacetaminophen has been shown to occur via an initial first- order dehydration step to N-acetyl-p-benzoquinone imine with a rate constant at pH 7.6 of 8.66 X low3 mid and a half-life of 80 min. This is followed by a complex reaction between the quinone imine and the N-hydroxy compound to ultimately yield p-nitrosophenol and acetaminophen. The glucuronide and sulfate conjugates of N-hydroxyacetaminophen ...
