Abstract Condensation of bis-(2-chloroethyl) phosphoramidic dichloride with 3′-amino-3′- deoxy-N, N-dimethyladenosine afforded the 2′, 3′-cyclicphosphorodiamidate (III). By an improved synthesis, methyl 3-amino-3-deoxy-β-D-ribofuranoside was obtained as a model compound for conversion to the analogous 2, 3-cyclicphosphorodiamidate (XII). Existence of the latter as two diastereomers due to phosphorus asymmetry was shown by nmr analysis, ...