Synthesis and in vitro Antibacterial Activities of 5??(2, 3, 4, 5??Tetrahydro??1H??chromeno [2, 3??d] pyrimidin??5??yl) pyrimidione Derivatives

Q Cheng, Q Wang, T Tan, M Wang…

Index: Cheng, Qingfang; Wang, Qifa; Tan, Ting; Wang, Mingxiao; Chen, Na Chinese Journal of Chemistry, 2012 , vol. 30, # 2 p. 386 - 390

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Citation Number: 5

Abstract

Abstract A series of novel 5-(2, 3, 4, 5-tetrahydro-1H-chromeno [2, 3-d] pyrimidin-5-yl) pyrimidione derivatives have been synthesized from substituted salicylaldehydes and barbituric acid or 2-thiobarbituric acid in water catalyzed by phase transfer catalysis of triethylbenzyl ammonium chloride (TEBA). Elemental analysis, IR, 1 H NMR, and 13 C NMR elucidated the structures of all the newly synthesized compounds. In vitro antimicrobial ...