The synthesis and SAR study of phenylalanine-derived (Z)-5-arylmethylidene rhodanines as anti-methicillin-resistant Staphylococcus aureus (MRSA) compounds

BA Patel, CR Ashby, D Hardej, TT Talele

Index: Patel, Bhargav A.; Ashby Jr., Charles R.; Hardej, Diane; Talele, Tanaji T. Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 20 p. 5523 - 5527

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Citation Number: 14

Abstract

Abstract A focused library of rhodanine compounds containing novel substituents at the C5- position was synthesized and tested in vitro against a panel of clinically relevant MRSA strains. The present SAR study was based on our lead compound 1 (MIC= 1.95 μg/mL), with a focus on identifying optimal C5-arylidene substituents. In order to obtain this objective, we condensed several unique aromatic aldehydes with phenylalanine-derived rhodanine ...