Synthesis and biological evaluation of pyrimidine analogs of antimycobacterial purines

…, M Brændvang, PO Miranda, LL Gundersen

Index: Read, Matthew L.; Braendvang, Morten; Miranda, Pedro O.; Gundersen, Lise-Lotte Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 11 p. 3885 - 3897

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Citation Number: 23

Abstract

Pyrimidine analogs of antimycobacterial 6-aryl-9-benzylpurines have been synthesized and screened for antibacterial activity against Mycobacterium tuberculosis H37Rv in vitro. Several active compounds were identified and the best results were observed for 5- formamidopyrimidines. These compounds generally displayed IC90 values≤ 1μg/mL, and they exhibited low toxicity towards mammalian cells. Imidazolylpyrimidines, which may be ...