Isolation and identification of impurities in 4??acetyl??2??(2′??hydroxyethyl)??5, 6??bis (4??chlorophenyl)??2H??pyridazin??3??one, an antihypertensive agent

LJ Powers, DJ Eckert, L Gehrlein

Index: Powers; Eckert; Gehrlein Journal of Pharmaceutical Sciences, 1981 , vol. 70, # 4 p. 419 - 421

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Citation Number: 4

Abstract

Abstract Three trace impurities found in 4-acetyl-2-(2′-hydroxy-ethyl)-5, 6-bis (4- chlorophenyl)-2H-pyridazin-3-one (II), a novel anti-hypertensive agent, were isolated by a combination of low-pressure liquid chromatography and preparative TLC. These impurities