Bioorganic & medicinal chemistry letters

Docking studies and development of novel 5-heteroarylamino-2, 4-diamino-8-chloropyrimido-[4, 5-b] quinolines as potential antimalarials

AA Joshi, CL Viswanathan

Index: Joshi, Advait A.; Viswanathan Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 10 p. 2613 - 2617

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Citation Number: 55

Abstract

MOE-Dock (Docking software) was used to predict the binding modes of 10 novel and potent 5-substituted amino-2, 4-diamino-8-chloropyrimido-[4, 5-b] quinolines (compounds I–X) as part of our antimalarial drug development programme. This was done by analyzing the interaction of these compounds with the active sites of 11 enzymes present in Plasmodium falciparum and based on this, effective binding was observed to enzyme P. falciparum ...