Synthesis

Synthesis of 3-hydroxypyrimidine-2, 4-diones. Addition of anilines to benzyloxy isocyanate synthons to give N-hydroxyureas

JL Romine, SW Martin, NA Meanwell, JR Epperson

Index: Romine; Martin; Meanwell; Epperson Synthesis, 1994 , # 8 p. 846 - 850

Full Text: HTML

Citation Number: 9

Abstract

A review of the literature yielded few reports that dealt with the utility of alkoxy isocyanates. 5 This is because most attempts to generate them have been unsuccessful due to their tendency to trimerize. 6 In 1960, McKay iso-lated the 1, 3, 5-tribenzyloxyisocyanuric acid 2 when tri-ethylamine was added to a solution of benzyloxyarnine hydrochloride and phosgene which had been heated at reﬂux in chlorobenzene7 (Scheme 2). In the ...

~90%

~90%

6-Hydroxy-1, 2, 4-triazine-3, 5 (2 H, 4 H)-dione Derivatives...

[Berry, James F.; Rais, Rana; Slusher, Barbara S.; Tsukamoto, Takashi; Ferraris, Dana V.; Duvall, Bridget; Hin, Niyada; Alt, Jesse; Thomas, Ajit G.; Rojas, Camilo; Hashimoto, Kenji Medicinal Chemistry letters, 2012 , vol. 3, # 10 p. 839 - 843,5 Title/Abstract Full Text Show Details Berry, James F.; Ferraris, Dana V.; Duvall, Bridget; Hin, Niyada; Rais, Rana; Alt, Jesse; Thomas, Ajit G.; Rojas, Camilo; Hashimoto, Kenji; Slusher, Barbara S.; Tsukamoto, Takashi ACS Medicinal Chemistry Letters, 2012 , vol. 3, # 10 p. 839 - 843]