Asymmetric transformation of (RS)-cysteine via formation of (RS)-4-thiazolidinecarboxylic acids.

…, K Kataoka, S Sakata, H Kurokawa

Index: Shiraiwa, Tadashi; Kataoka, Kazuo; Sakata, Shinji; Kurokawa, Hidemoto Bulletin of the Chemical Society of Japan, 1989 , vol. 62, # 1 p. 109 - 113

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Citation Number: 17

Abstract

Either (R)-or (S)-cysteine ((R)-or (S)-Cys) was efficiently obtained from (RS)-Cys by the asymmetric transformation via formation of (RS)-4-thiazolidinecarboxylic acid ((RS)-THC) or (RS)-2, 2-dimethyl-4-thiazolidinecarboxylic acid ((RS)-DMT) and by using (2R, 3R)-or (2S, 3S)-tartaric acid ((R)-or (S)-TA), as a resolving agent, in acetic acid. The asymmetric transformation was carried out by combination of crystallization of less soluble salt of (S)- ...