Based on the observed biological activities of coumarins and resveratrol, we synthesized fourteen hydroxylated 3-phenylcoumarins (stilbene-coumarin hybrids) including six novel ortho-hydroxy-methoxy substituted derivatives, 1–14, by Perkin reaction. We characterized these compounds concerning their antioxidant activity against 2, 2′-azobis (2- amidinopropane hydrochloride)(AAPH)-induced pBR322 DNA strand breakage, and their ...