e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
The Journal of organic chemistry
Synthesis of optically pure (+)-puraquinonic acid and assignment of absolute configuration to natural (-)-puraquinonic acid. Use of radical cyclization for asymmetric …
DLJ Clive, M Yu, M Sannigrahi
Index: Clive, Derrick L. J.; Yu, Maolin; Sannigrahi, Mousumi Journal of Organic Chemistry, 2004 , vol. 69, # 12 p. 4116 - 4125
An asymmetric aldol reaction between aldehyde 31 and imide 32, followed at a later stage by ring-closing metathesis (38→ 40), are key reactions used to make optically pure allylic alcohol 40. Radical cyclization of the derived Stork bromo acetals gives lactol ethers 43, which were degraded to generate a quaternary center carrying a methoxycarboxyl group (44→ 47). Compound 47 was converted into (+)-puraquinonic acid; and comparison with ...
[Womack, Gary B.; Angeles, John G.; Fanelli, Vincent E.; Indradas, Brinda; Snowden, Roger L.; Sonnay, Philippe Journal of Organic Chemistry, 2009 , vol. 74, # 15 p. 5738 - 5741]
