In a previous paper'it was shown that acetylsulfanilyl chloride would not react with 4-(a- carbethoxyalkyl)-2-aminothiazoles nor in one instance with the free acid itself. However, the 4-alkyl substituted aminothiazole, obtained by the decarboxylation of these acids reacted readily with the chloride even though the side chain was seven carbons long. From this it was assumed that the carboxy or carbethoxy group exerted an inhibitory effect upon the ...
