New antitumor agent—Spirobromin

…, SM Minakova, MI Dorokhova, LG Levkovskaya…

Index: Safonova, T. S.; Chernov, V. A.; Minakova, S. M.; Dorokhova, M. I.; Levkovskaya, L. G.; et al. Pharmaceutical Chemistry Journal, 1983 , vol. 17, # 5 p. 375 - 377 Khimiko-Farmatsevticheskii Zhurnal, 1983 , vol. 17, # 5 p. 626 - 629

Full Text: HTML

Citation Number: 1

Abstract

With this aim the interaction has been studied of N', N"-dispirotripiperazinium dichloride (Ia) with the acid chloride of B-bromopropionic acid. Reaction was effected in aqueous medium or a medium of wa~ er and ether with basic agents such as LiOH or NaHCO3 used as acceptors to bind the hydrogen chloride formed in the reaction process. N, N'"-Di (B- bromopropionyl)-N', N"-dispirotripiperazinium dichloride (IIa) was obtained in this way. To ...