2-Hydroxy-6-methyl-1: 5-naphthyridine (I1; R= OH) has been converted into 2-chlovo-6- methyl-1: 5-nuphthyridine, and hence into a number of 2-substituted 6-methyl-1: 5- nufihthyridines. Application of the Doebner-Miller reaction to 5-amino-N-methyl-2-pyridone,