Chinese Chemical Letters

Efficient synthesis of 4-substituted pyrazole via microwave-promoted Suzuki cross-coupling reaction

H Cheng, QY Wu, F Han, GF Yang

Index: Cheng, Hua; Wu, Qiong-You; Han, Fan; Yang, Guang-Fu Chinese Chemical Letters, 2014 , vol. 25, # 5 p. 705 - 709

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Citation Number: 5

Abstract

Abstract Pyrazoles and their derivatives are important heterocycles found in nature and present in numerous bioactive compounds. In contrast to 3 or 5-aryl pyrazole, the preparation of 4-aryl pyrazole is fairly rare. Utilizing microwave irradiation, the synthesis of 4- substituted-arylpyrazole via Suzuki cross-coupling has been developed with a wide range of substrates. The remarkable advantages of this method are mild reaction conditions, ...