Hydrogenolysis of 3-(benzyloxy) cyclophosphamide (10) using Pd/C catalyst and ethyl acetate as solvent leads to the formation of 3-hydroxycyclophosphamide (3,-20%) and cyclophosphamide (1,-10%), accompanied by regioselective hydrogen-exchange reactions at the C-4 and C-5 positions in 3 and 1. A variety of oxidizing reagents and liver microsomal incubation failed to provide evidence NMR) for conversion of 1 into 3, whereas identical ...
![4H-1,3,2-Oxazaphosphorin-4-one,2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide Structure](https://image.chemsrc.com/caspic/376/27046-19-1.png)
