Molecules

Preparation of 6-substituted quinoxaline JSP-1 inhibitors by microwave accelerated nucleophilic substitution

L Zhang, B Qiu, X Li, X Wang, J Li, Y Zhang, J Liu, J Li…

Index: Zhang, Li; Qiu, Beiying; Li, Xin; Wang, Xin; Li, Jingya; Zhang, Yongliang; Liu, Jian; Li, Jia; Shen, Jingkang Molecules, 2006 , vol. 11, # 12 p. 988 - 999

Full Text: HTML

Citation Number: 11

Abstract

Abstract: A small library of 6-aminoquinoxalines has been prepared by nucleophilic substitution of 6-fluoroquinoxaline with amines and nitrogen-containing heterocycles under computer-controlled microwave irradiation. Some compounds were found to be potent inhibitors of JNK Stimulatory Phosphatase-1 (JSP-1) in an in vitro biological assay.