Abstract A novel method for the synthesis of aryl-substituted guanidines in good overall yields is presented; it consists of the acidic cleavage of 2-(arylamino)-4, 6- dimethoxypyrimidines, which were prepared by coupling aryl bromides with 2-amino-4, 6- dimethoxypyrimidine. This methodology introduces a new means of protection for the guanidine functionality.
