Tetrahedron Letters

AgNO 3 catalyzed synthesis of 5-substituted-1H-tetrazole via [3+ 2] cycloaddition of nitriles and sodium azide

P Mani, AK Singh, SK Awasthi

Index: Mani, Pavnesh; Singh, Ashawani Kumar; Awasthi, Satish Kumar Tetrahedron Letters, 2014 , vol. 55, # 11 p. 1879 - 1882

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Citation Number: 24

Abstract

Abstract An efficient one-pot, convenient catalysis for the synthesis of 5-substituted-1H- tetrazoles is reported. The [3+ 2] cycloaddition involves various nitriles, sodium azide in refluxing DMF and AgNO 3 as catalyst to give corresponding 5-substituted-1H-tetrazoles in good to excellent yields. It is expected that the reaction proceeds via in situ formation of a silver azide species, which participates in coordination of nitrile moiety followed by ...