Stereoselective formation and metabolism of 4-hydroxy-retinoic Acid enantiomers by cytochrome p450 enzymes

JA Shimshoni, AG Roberts, M Scian, AR Topletz…

Index: Shimshoni, Jakob A.; Roberts, Arthur G.; Scian, Michele; Topletz, Ariel R.; Blankert, Sean A.; Halpert, James R.; Nelson, Wendel L.; Isoherranen, Nina Journal of Biological Chemistry, 2012 , vol. 287, # 50 p. 42223 - 42232

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Citation Number: 16

Abstract

Background: CYP26A1 is a critical enzyme in the metabolism of all-trans-retinoic acid (atRA). Results: CYP26A1 metabolizes atRA stereoselectively to (4S)-OH-RA, which corresponds to atRA orientation within the CYP26A1 active site. Conclusion: Preference for (4S)-OH-RA is conserved in atRA metabolism and in elimination of 4-OH-RA.