Antibacterial profile against drug-resistant Staphylococcus epidermidis clinical strain and structure–activity relationship studies of 1H-pyrazolo [3, 4-b] pyridine and …

…, IF Afonso, CR Rodrigues, PA Abreu, R Garrett…

Index: Leal, Bruno; Afonso, Ilidio F.; Rodrigues, Carlos R.; Abreu, Paula A.; Garrett, Rafael; Pinheiro, Luiz Carlos S.; Azevedo, Alexandre R.; Borges, Julio C.; Vegi, Percilene F.; Santos, Claudio C.C.; da Silveira, Francisco C.A.; Cabral, Lucio M.; Frugulhetti, Izabel C.P.P.; Bernardino, Alice M.R.; Santos, Dilvani O.; Castro, Helena C. Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 17 p. 8196 - 8204

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Citation Number: 37

Abstract

Antibacterial resistance is a complex problem that contributes to health and economic losses worldwide. The Staphylococcus epidermidis is an important nosocomial pathogen that affects immunocompromised patients or those with indwelling devices. Currently, there are several resistant strains including S. epidermidis that became an important medical issue mainly in hospital environment. In this work, we report the biological and theoretical ...