Index: Alabaster, Valerie A.; Campbell, Simon F.; Danilewicz, John C.; Greengrass, Colin W.; Plews, Rhona M. Journal of Medicinal Chemistry, 1987 , vol. 30, # 6 p. 999 - 1003
Bz BZ H activity between 11 and 24 corresponds to a 1.68 kcal/mol increase in binding energy, which may support a specific hydrophobic interaction between the aromatic ring and the receptor protein. 6 Separation of the carboxamide moiety from the piperidine ring by alkyl or alkoxyalkyl bridges of varying lengths (26-30) had only minor influence on a,- adrenoceptor activity.
