4-Dihydroxyborylphenyl analogues of 1-aminocyclobutanecarboxylic acids: potential boron neutron capture therapy agents

RR Srivastava, RR Singhaus…

Index: Srivastava, Rajiv R.; Singhaus, Robert R.; Kabalka, George W. Journal of Organic Chemistry, 1999 , vol. 64, # 23 p. 8495 - 8500

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Citation Number: 49

Abstract

A series of 4-dihydroxyborylphenyl analogues of an unnatural α-amino acid, 1- aminocyclobutanecarboxylic acid (ACBC), was synthesized. Varying numbers of methylene units were introduced between the 4-boronophenyl and ACBC moieties in order to introduce different degrees of lipophilicity into the molecules. The key step in the syntheses was the preparation of the precursor p-boronophenyl-substituted cyclobutanones which were ...