Model systems for flavoenzyme activity: relationships between cofactor structure, binding and redox properties

YM Legrand, M Gray, G Cooke…

Index: Legrand, Yves-Marie; Gray, Mark; Cooke, Graeme; Rotello, Vincent M. Journal of the American Chemical Society, 2003 , vol. 125, # 51 p. 15789 - 15795

Full Text: HTML

Citation Number: 60

Abstract

A series of flavins were synthesized bearing electron-withdrawing and-donating substituents. The electrochemical properties of these flavins in a nonpolar solvent were determined. The recognition of these flavins by a diamidopyridine (DAP) receptor and the effect this receptor has on flavin redox potential was also quantified. It was found that the DAP-flavin binding affinity and the reduction potentials (E 1/2) for both the DAP-bound and ...