It has been reported that trialkylacetamidesl (I), trialkylethylamines2 (11) and trialkylacetic acids3 (111), in which R is a 3, 4 or 5 carbon atom alkyl group and R3 totals 12-18 carbon atoms, possess musculotropic antispasmodic activity equal to or greater than papaverine. In order to establish whether the structural requirements for antispasmodic activity observed for I, I1 and I11 are generally applicable to highly branched, aliphatic compounds, we ...
