Amino Acids

Stereoselective introduction of two chiral centers by a single diketoreductase: an efficient biocatalytic route for the synthesis of statin side chains

X Wu, L Wang, S Wang, Y Chen

Index: Wu, Xuri; Wang, Lili; Wang, Shuzhen; Chen, Yijun Amino Acids, 2010 , vol. 39, # 1 p. 305 - 308

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Citation Number: 26

Abstract

Abstract Statins, including atorvastatin (Lipitor®), are the top-selling drugs in the world. The biocatalytic production of chiral side chains of statin drugs is of great interest to academia and industry. Stereoselective double reduction of a β, δ-diketo ester catalyzed by a diketoreductase offers a simple and efficient route for the preparation of statin side chains. Comparison of different cofactor regeneration systems resulted in an easy and cost- ...