Structure-activity relationships of 9-alkyladenine and ribose-modified adenosine derivatives at rat A3 adenosine receptors

KA Jacobson, SM Siddiqi, ME Olah, X Ji…

Index: Jacobson, Kenneth A.; Siddiqi, Suhaib M.; Olah, Mark E.; Ji, Xiao-duo; Melman, Neli; et al. Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1720 - 1735

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Citation Number: 76

Abstract

9-Alkyladenine derivatives and ribose-modified W-benzyladenosine derivatives were synthesized in an effort to identify selective ligands for the rat & adenosine receptor and leads for the development of antagonists. The derivatives contained structural features previously determined to be important for & selectivity in adenosine derivatives, such as an W (3-iodobenzyl) moiety, and were further substituted at the 2-position with halo, amino, or ...