Fused bicyclic Gly-Asp β-turn mimics with potent affinity for GPIIb-IIIa. Exploration of the arginine isostere

MJ Fisher, U Giese, CS Harms, MD Kinnick…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 10, # 4 p. 385 - 389

Full Text: HTML

Citation Number: 14

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... Removal of the Cbz group with hydrogen and palladium provided secondary amine Scheme 1 and Scheme 2, which was transformed into the target molecule Scheme 1 and Scheme 2 using chemistry similar for the preparation of ...