Direct alkynylation of indole and pyrrole heterocycles

JP Brand, J Charpentier, J Waser

Index: Brand, Jonathan P.; Charpentier, Julie; Waser, Jerome Angewandte Chemie - International Edition, 2009 , vol. 48, # 49 p. 9346 - 9349

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Citation Number: 228

Abstract

Indoles and pyrroles occupy a privileged position in pharmaceuticals, material sciences, and natural products.[1] Consequently, methods to synthesize and functionalize these heterocycles are of utmost importance in organic chemistry.[2] Metal-catalyzed cross- coupling is the method most often used for the introduction of (hetero) aryl, vinyl, or acetylene groups to indoles and pyrroles, but it requires premodification of the heterocycle ...