Tetrahedron letters

Efficient synthesis of 3-substituted 2, 3-dihydroquinolin-4-ones using a one-pot sequential multi-catalytic process: Pd-catalyzed allylic amination–thiazolium salt- …

T Nemoto, T Fukuda, Y Hamada

Index: Nemoto, Tetsuhiro; Fukuda, Tomoaki; Hamada, Yasumasa Tetrahedron Letters, 2006 , vol. 47, # 26 p. 4365 - 4368

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Citation Number: 57

Abstract

We developed an efficient method for the synthesis of 3-substituted 2, 3-dihydroquinolin-4- ones using a one-pot sequential multi-catalytic process: Pd-catalyzed allylic amination– thiazolium salt-catalyzed Stetter reaction cascade. Measurement of the initial rate of the developed sequential process revealed a significant increase in the reaction rate of the Stetter reaction in the presence of Pd (OAc) 2 and AcOH· i-Pr2NEt, the constituents of the ...