Synthesis of Anti??Microtubule N??(2??Arylindol??7??yl) benzenesulfonamide Derivatives and Their Antitumor Mechanisms

…, GS Chen, ML Chen, H Li, L Shi, XH Huang…

Index: Chiou, Chun-Tang; Chen, Grace Shiahuy; Chen, Meng-Ling; Li, Huoming; Shi, Lei; Huang, Xiang-Hong; Dai, Wei-Ming; Chern, Ji-Wang ChemMedChem, 2010 , vol. 5, # 9 p. 1489 - 1497

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Citation Number: 8

Abstract

Prostate cancer is one of the most common cancers in men worldwide, and its incidence has increased even in the last few years.[1–3] Clinically, patients with prostate cancer initially respond effectively to androgen depletion therapy, which induces apoptosis of tumor cells.[4] However, androgen depletion therapy becomes ineffective in most patients after a period of time. In these hormone-refractory prostate cancer cases, tumors become metastatic and ...