Synthesis of novel diazatricyclodecanes (DTDs). Effects of structural variation at the C3′ allyl end and at the phenyl ring of the cinnamyl chain on μ-receptor affinity …

…, G Cignarella, S Ruiu, G Loriga, G Murineddu…

Index: Pinna, Gerard Aime; Cignarella, Giorgio; Ruiu, Stefania; Loriga, Giovanni; Murineddu, Gabriele; Villa, Stefania; Grella, Giuseppe Enrico; Cossu, Gregorio; Fratta, Walter Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 18 p. 4015 - 4026

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Citation Number: 13

Abstract

Two series of analogues of 9-propionyl-10-cinnamyl-9, 10-diazatricyclo [4.2. 1.12, 5] decane (1a) and 2-propionyl-7-cinnamyl-2, 7-diazatricyclo [4.4. 0.03, 8] decane (2a), in which the cinnamyl moiety was replaced by various aralkenyl chains, 1b–l and 2b–l, respectively, have been synthesized and evaluated for their ability to bind to the opioid μ-, δ-and κ-receptors. The binding data indicated that compounds 1b, d, e, h and 2b, d, e, f, h, i showed a μ- ...

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