Design, synthesis and molecular docking studies of some novel spiro [indoline-3, 4′-piperidine]-2-ones as potential c-Met inhibitors

…, H Jin, Z Zhu, S Wan, J Zhang, P Yu, J Zhang…

Index: Ye, Lianbao; Tian, Yuanxin; Li, Zhonghuang; Jin, Hong; Zhu, Zhengguang; Wan, Shanhe; Zhang, Junyan; Yu, Pengjiu; Zhang, Jiajie; Wu, Shuguang European Journal of Medicinal Chemistry, 2012 , vol. 50, p. 370 - 375

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Citation Number: 16

Abstract

Deregulation of receptor tyrosine kinase c-Met has been reported in human cancers and is considered as an attractive target for small molecule drug discovery. In this study, a series of spiro [indoline-3, 4′-piperidine]-2-ones were designed, synthesized and evaluated as novel c-Met inhibitors. The results showed that the majority of the compounds exhibited significant inhibitory effect on c-Met with IC50 values of 0.0147–17 μM in TR-FRET-based ...