The C N cross-coupling reaction between aromatic halides and amides has now been applied to 2-and 3-substituted bromofurans and bromothiophenes. Catalytic CuI in the presence of N, N′-dimethylethylenediamine as a ligand and K3PO4 or K2CO3 as the base furnished 2-and 3-substituted amidofurans and thiophenes ranging from 11 to 99% depending on the particular amide source used.
