Synthesis of New 1, 4-Dihydropyridine Derivatives Containing Thiazolyl Substituents

…, A Shafiee, M Amini, EB Dezfouli, E Azizi…

Index: Bazargan, Leila; Shafiee, Abbas; Amini, Mohsen; Dezfouli, Ebrahim Bakhshi; Azizi, Ebrahim; Ghaffari, Seyed Mahmood Phosphorus, Sulfur and Silicon and the Related Elements, 2009 , vol. 184, # 3 p. 602 - 609

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Citation Number: 2

Abstract

A series of 4-[2-methyl (or aryl) thiazole-4-yl]-2, 6-dimethyl-3, 5-diacetyl (or dibenzoyl) 1, 4- dihydropyridines were synthesized using a modified Hantzsch reaction involving the condensation of the corresponding aldehyde with acetyl acetone or benzoyl acetone. The preparation of the corresponding aldehydes (2-methylthiazole-4-carboxaldehyde and some 2-arylthiazole-4-carboxaldehydes) was achieved by a simplified protocol of the published ...